INDUCTION OF S-METcitation_listACHLOR PRENEOPLASTIC LIVER LESION IN RAT INITIATED CARCINOGENESIS BY NITROSODIETHYLAMINE
نویسندگان
چکیده
منابع مشابه
Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis
Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer. Previously, we reported that quercetin has a chemopreventive effect on the liver-induced preneoplastic lesions in rats. Here, we evaluated if quercetin was able not only to prevent but also to reverse rat liver preneoplastic lesions. We used the modified resistant hepatocyte model (MRHM) to evaluate...
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The question of whether 8-hydroxyguanine (8-OHG) formation is involved in initiation by low dose levels of N-nitrosodiethylamine (DEN) was addressed using a rat liver model. Male Fischer 344 rats, 6 weeks of age, were administered single i.p. doses of DEN between 0.001 and 100 mg/kg body weight. The 8-OHG levels in liver DNA were measured within 72 h thereafter in randomly selected rats. The re...
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The promoting activities of 29 compounds on induction of hyperplastic (neoplastic) liver nodules (HN) and the dose-dependent effects of tumor promoting agents were compared by using a short-term test system developed in this laboratory. In tests on promoting activity, F344 rats were given a single dose (200 mg/kg) of N-nitrosodiethylamine (DEN), and from two weeks later, were treated with vario...
متن کاملDose response studies of carcinogenesis in rats by nitrosodiethylamine.
A dose-response study was conducted in Fischer rats with nitrosodiethylamine, which was administered in regulated amounts as a solution in drinking water. Groups of 20 female rats each received a different treatment, one group consisted of 12 animals; one of the groups was untreated. The concentrations of the solutions fed ranged from 113 to 0.45 mg/liter at six successive concentrations differ...
متن کاملInduction of autophagy promotes the growth of early preneoplastic rat liver nodules
Although inhibition of autophagy has been implicated in the onset and progression of cancer cells, it is still unclear whether its dysregulation at early stages of tumorigenesis plays an oncogenic or a tumor suppressor role. To address this question, we employed the Resistant-Hepatocyte rat model to study the very early stages of hepatocellular carcinoma (HCC) development. We detected a differe...
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ژورنال
عنوان ژورنال: Bulletin of Problems Biology and Medicine
سال: 2019
ISSN: 2077-4214,2523-4110
DOI: 10.29254/2077-4214-2019-2-1-150-270-274